OPRM1 Genotyping

Mu 1 opioid receptor (OPRM1) is a pharmacodynamic receptor that is partly responsible for opioid effectiveness and is associated with pain sensitivity, substance dependence and abuse. The most analyzed genetic variants in the pain field, known as c.118A>G, have shown an association with opioid effectiveness, but the correlation is small and not always replicated in studies. The c.118A>G polymorphism has also shown a correlation with naltrexone efficacy in the treatment of alcoholism and addiction risk to opioids, including heroin.


Indications for Testing

Patients beginning naltrexone treatment for alcohol dependence would be good candidates for OPRM1 testing. Testing can also help predict opioid response and dose requirements. In patients of Asian descent, testing can help assess opioid addiction risk.


Insurance Coverage

OPRM1 testing is currently not covered by Medicare. Private insurance coverage varies by insurance company. The CPT code for OPRM1 testing is 81479 (provided for your guidance only).


Specimen Collection

Click here to order testing supplies or call Client Services at 800-837–8362.

  • Buccal Swabs: 4 sterile buccal swabs
  • Blood: 5-10cc whole blood lavender-top EDTA or yellow-top ACD-A tubes

Turnaround Time: 7 business days, faster turnaround available for clinical trials