Cytochrome P-450 1A2 Genotyping

CYP1A2 is part of the cytochrome P450 family of drug-metabolizing enzymes and is responsible for metabolism of approximately 9 percent of prescription drugs. Multiple variants, also known as alleles, have been associated with altered enzyme activity, and therefore would be associated with drug metabolism and altered drug exposure. CYP1A2 metabolizes many common medications and substances, including theophylline, melatonin, clopidogrel, clozapine and caffeine.


Indications for Testing

Patients who smoke and require treatment with clozapine and clopidogrel1 may represent good candidates for testing. More clinical evidence is needed to establish a strong cause and effect between the CYP1A2 phenotypes and drug exposure before testing can be routinely recommended. Assessment of medical necessity for testing is up to the provider’s clinical judgment.


Insurance Information

CYP1A2 testing is currently not covered by Medicare. Private insurance coverage varies by insurance company. The CPT code for CYP1A2 testing is 81479 (provided as guidance only).


Specimen Information

Click here to order testing supplies or call Client Services at 800-837–8362.

  • Buccal Swabs: 4 sterile buccal swabs
  • Blood: 5-10cc whole blood lavender-top EDTA or yellow-top ACD-A tubes

Turnaround Time: 5 days, 4 day STAT