5HTT Genotyping

Serotonin is a neurotransmitter, a chemical that transmits signals from one nerve cell to another, and changes in the levels of this chemical have been associated with some behavioral disorders. Certain psychiatric medications help treat these disorders by targeting 5HTT, a protein that helps naturally regulate serotonin levels. However, genetic changes to 5HTT can decrease the effectiveness of these medications and increase the risk of adverse effects.


Indication for Testing

Patients who are initiating SSRI or other 5HTT-targeting therapies, or experiencing adverse effects or low efficacy should consider 5HTT genotyping.


CPT Codes

(provided for guidance only)
5HTT Mutation DNA Analysis:  81479


Specimen Collection

Click here to order testing supplies or call Client Services at 800-837–8362. 

  • Buccal Swabs: 4 sterile buccal swabs
  • Blood: 5-10cc whole blood lavender-top EDTA or yellow-top ACD-A tubes

Turnaround Time: 7 business days, faster turnaround available for clinical trials