Praise From Our Valued Clients
Physicians, pharmacists, medical researchers, and people just like you have contacted us to praise the Genelex DNA sensitivity testing powered by the YouScript Personalized Prescribing System. While we are pleased so many value the service we provide, our highest achievement will be realized when YouScript® reduces the severity and number of drug side effects.
“I used to suffer from horrific side effects as bad as the condition being treated. Your testing has changed that. I am very grateful! Thank you!”
A.W., King of Prussia, PA
“I just wanted to tell you that my physician switched my medications based on my test results, and I cannot describe how much better I feel. You have made a believer out of me, my family, and my physician. I hope this testing becomes routine before anyone is placed on long-term medication.”
P.Y., Eirie, CO
“I have been having drug reactions for years and my doctors told me it was in my head. Now I have proof that I’m a poor metabolizer for many medications. I just wish I’d known about your test years ago. Thank you for providing this service!”
M.D., Syracuse, NY
“Thank you for this potential lifesaving information. I will be referring friends and family members for testing.”
D.L., Manlius, NY
Real Stories, Real People
Tom Carlson, a Minnesota entrepreneur, shares his story of how genetic testing and personalized medicine averted tragedy in his family.
“It has been known for years that people react differently to medications. If you know and understand your enzyme situation, you can learn which prescription drugs are best and worst for you. A simple genetic test can mean the difference between a drug that makes you well and one that gives you a toxic reaction or has no effect at all. Despite these tests being around for the last few years, a recent study found that only “1 in 4 physicians had any education in the use of genetic testing to guide medical decisions,” and many people are unaware of how far personalized medicine has come.
My family and I have experienced first-hand how pivotal this information is. We have all been tested, and it has been very influential in improving our health care. Members of my family have suffered and almost died from being prescribed medications that did not match their unique and genetically determined drug metabolizing enzymes.
My dad almost died from a bad drug-gene interaction in 2008 caused by a common prescription pain-killer. Even though he explained to his health care providers that, like 10% of the population, he is a poor metabolizer of the CYP2D6 enzyme, he was still prescribed the wrong pain medication after surgery. His caregivers did not understand the drug-metabolizing enzyme information he provided, and he was prescribed a medication smetabolized solely by CYP2D6. He rapidly became very sick, and experienced no pain relief. I thought he was going to die in front of me. As he was suffering, I went on the web and learned that thousands have died from the combination of drugs and being a CYP2D6 poor metabolizer.
My mother also had a problem with Coumadin, a common blood thinner, which could have been very serious. Like 35% of the population, she is an intermediate metabolizer of the CYP2C9 enzyme, which metabolizes the blood thinner. She told her caregivers about her enzyme deficiency, but they did not know of the tests or what my mom’s meant. Worse yet, they did not tell her they did not understand. These caring, smart, hardworking people proceeded to give her way too much blood thinner. When she returned to get her blood checked, they discovered that her blood had become dangerously thin, and there was a risk that she could bleed to death.
These incidents—and others I can’t name here—could have, and should have, been prevented!
Please realize I am not a physician and take no liability for your decisions. Talk to your doctors, pharmacists, and nurses and find out if they are familiar with this testing. I have talked to many highly regarded physicians who were not familiar with these tests. They greatly appreciated the information I shared, and some even changed how they prescribed medications to members of my family. One physician told me, “Of course we have seen different results in patients given the same medications, but we have never understood why – this makes total sense. Thanks for letting me know.”
Please pass this information along—knowledge and understanding of these tests needs to get to the public and medical community. You might save or improve a life!”
Ann Jessey of Salt Spring Island, British Columbia recounts how she benefited from DNA sensitivity testing, even as a normal metabolizer.
“I’m one of those people who likes to be informed and as a result, I constantly find myself knowing more than the medical professionals I deal with because healthcare systems take so long to catch up to new research and/or implement new procedures & protocols! I was prescribed 5 years of Tamoxifen following surgery for breast cancer and subsequently was intrigued to learn from various websites/newsletters that there are individual differences in the way medications are metabolized and that I needed to have a particular enzyme called CYP2D6 to metabolize Tamoxifen. Since I also discovered that testing for this enzyme was not available here in Canada, I contacted the closest lab (Genelex Lab in Seattle) and asked them to send me information on how to get the test. The first hurdle was obtaining the required authorization from my family doctor who was reluctant to do it because he’d never heard of the test but eventually he agreed to do so (with the proviso that any necessary changes to my prescription would have to be handled by my oncologist) so I agreed to that and he ordered it for me. It turned out I was a normal metabolizer of Tamoxifen – so no changes were required – but in the process, I made the very important discovery that this same enzyme that is critical to the metabolizing of Tamoxifen (CYP2D6) is the same one that is targeted by Celebrex (which my doctor wanted to prescribe for arthritis in my knees) so I had to explain to him why I shouldn’t/couldn’t take it!
At my annual check-up at British Columbia Cancer Agency in Victoria BC the following year, I asked for the results of my YouScript test to be added to my file – which generated a whole lot of questions from clinic staff (including the oncologist I saw that day) about the test so I explained it to them and was horrified to discover they’d never heard of it!! Oncologists at the clinic (who write hundreds of Tamoxifen prescriptions every year) clearly had no idea the test existed and that their patients were not only metabolizing the drug at different rates but some were unable to metabolize it at all!
The lesson I’ve learned is the importance of advocating for yourself when it comes to tests that may be available outside the existing medical system and/or unknown to your doctors so I requested the CYP2D6 test just as soon as I found out about it (a “no-brainer” at a mere $300) to find out if I was able to metabolize the Tamoxifen I’d been prescribed for 5 years – and it turned out I was – but sadly it’s not yet being offered to other breast cancer patients.
On a personal note, I’d like to mention that my contact at Genelex (Dan Doherty) was extremely helpful in providing me with all the information I needed about the test – and the logistics of getting it done across US/Canada border – so since then, I’ve referred several people to him and your organization and I hope these tests will soon be available to everyone.”
Ann goes on to tell about a friend whose experience with statins reveals the importance of knowing your genetic variation in order to avoid both potential physical and psychological complications.
“My friend was prescribed statins following a heart attack & subsequent heart surgery. After taking the drug for a while, he started having some major issues with depression (at one point, taking a plane to England without telling his wife) and he also developed diabetes which caused major problems with the muscles and circulation in his legs – which was especially distressing as he’d been a keen amateur cyclist competing in several local road races. His doctor was very concerned about this and referred him to one of the researchers at the Therapeutics Initiative at University of British Columbia in Vancouver where he was told he was one of about 10-15% of people who had this type of severe reaction to statins, that he should stop them at once, that the damage they’d caused to his legs was irreversible (and that he should warn his kids that they might have inherited the same genetic issue with statins). Within a week of coming off the drug, he was back to being the same person we’d known during the years before his heart surgery – no longer depressed and apologizing to his family and friends for his previous behaviour.”
Patricia, a cancer survivor from Seattle, explains how she learned firsthand the dramatic impact that drug sensitivities can have and how she was spared additional suffering with the help of DNA sensitivity testing.
“In 2005 I was diagnosed with breast cancer and had a right mastectomy. After the surgery I felt ‘strange’. The Dr. told me it was ‘stress from the cancer diagnosis……..and mental”. Given I am a Mental Health Therapist and very self aware – it didn’t ring true to me. Why? I had my office in the same location for many years, and yet I had to close the blinds due to extreme sensitivity to light since the surgery. (Central nervous system damage, FYI) I was anxious and felt mentally weird. They kept telling me it was mental. I suspected I was given drugs during my surgery that were making me ill (as had happened to my mom when she had a hysterectomy years ago). I changed doctors and entire clinic. At the new location I was told by my very experienced Oncologist that likely I was not able to process the drugs given to me in surgery (as I intuitively felt was the case, and it was nice to be taken seriously). He said that can happen and it might take as much as a few months to get it all out of me. That turned out to be the case. I got better, but slowly. I saw a Health Notes discussion at the end of a news program and they talked about Genelex. I decided to get tested for Drug Sensitivity. It was fast and easy, and I got a copy for myself (as well as online access, and a copy for my doctor). Turned out I am/was very drug sensitive and that the hospital/surgery gave me multiple medications I cannot metabolize/break down normally. Once I learned how drug pathways work, and what mine are – it made perfect sense why I had the symptoms and burden I had. Thanks to Genelex I was able to convince the surgeon to use completely different chemicals during my next surgery – which was a preventative hysterectomy (everything out: cervix, uterus, ovaries) and I obtained a fabulous outcome. I had no ‘hangover’ of chemicals after the surgery. We actually went camping shortly thereafter and I remained ‘my old self’. No light sensitivity, no anxiety, very grounded and the surgery (although major) was less impact on my body than a dentist visit (incidentally I also got drug sensitivity testing for dental products – so just know that exists as well). Bottom line: drug sensitivity testing should be done for everyone. Many people are sensitive to drugs…..or maybe can’t even break them down and get very sick (like I did). It is outrageous I was told by a seasoned Oncologist here in Seattle (the one I left and found another) that it was ‘mental’. Lots of physicians are ignorant about drug sensitivity testing. Or they know about it, but not don’t know what to do. It is a one size fits all mentality and it is deadly wrong. Genelex was key in my physical and mental health by giving me objective, reliable data about my body’s ability to break down drugs. (Incidentally, I have a Masters Degree from the University of Washington and felt outraged to be treated like a mental health patient when the whole problem was that I was chemically poisoned with multiple chemicals during surgery.) Again: the next surgery was easy and no problem in any way. I have lived almost 11 years past that cancer and apparently have no cancer return (without chemo or radiation). I refer people to Genelex often and know from personal experience the extreme value it had on my journey and health.”
If you have a story you’d like to share, we’d love to hear from you. Email email@example.com