Understanding Your Results

Congratulations! You have just received DNA sensitivity testing powered by YouScript to determine how your genes affect the enzymes that metabolize (break down) many commonly prescribed drugs.

The next step will be to review your test results with your doctor. Based on your unique genetic characteristics, and with the help of the YouScript Precision Prescribing System analytics software, your doctor will be able to prescribe drugs that are safe and effective for you.

Going forward, it is important that you share with all your healthcare providers the patient cards that came with your results. This information needs to be reviewed anytime medication changes are considered, to help select the safest and most effective drug and dose for you. Always consult with your doctor before you start or stop a medication or change how much you take.

The enzymes that are affected by your genes belong to a large family called CYP450. Just a few of the many CYP450 enzymes do most of the work required to metabolize the drugs we take. After a drug is metabolized, it is eliminated from the body. These enzymes are extremely important, because the effect they have on drugs can change – sometimes drastically – the effect that drugs have on us. Approximately 85 % of Americans have genetic variations that influence how these enzymes metabolize drugs.

Your unique profile for each of these enzymes has been identified. The YouScript Precision Prescribing System then developed a report to explain how each of your enzymes metabolizes drugs. The results of this test will not change in your lifetime. Each enzyme that was tested is categorized as follows:

  • Normal Metabolizer. A normal-metabolizing enzyme can generally break down standard doses of a drug.
  • Intermediate Metabolizer. An intermediate-metabolizing enzyme is considered to be less active. It doesn’t break down a drug as completely as a normal metabolizer, which means you might require a lower dose. A lower dose prevents the unmetabolized drug from building up in your body and possibly causing side effects.
  • Poor Metabolizer. A poor-metabolizing enzyme has very low activity. It is possible to have side effects even with a very low drug dose, because the enzyme is very slow to break down the drug.
  • Rapid or Ultrarapid Metabolizers. These enzymes are very active, often breaking down drugs before they can have any effect. If you metabolize a drug in this way, you may require a higher dose in order for the drug to work properly.

In addition to describing how your enzymes metabolize drugs, your report also provides detailed information and prescribing recommendations about each of the drugs you are currently taking.

Discuss this information with your doctor, or you can call 800-TEST-DNA if you still have questions on what your results mean. Pharmacists and other support staff are here to help.