FAQs

Q: What is Pharmacogenetic Testing?

Pharmacogenetic testing, also called DNA Drug Sensitivity Testing, is the testing of certain genes to determine how individuals are going to react to specific medications. This greatly decreases the need for trial and error” dosing and can reduce the risk of Adverse Drug Reactions (ADRs) substantially.

Pharmacogenetics testing is a new tool in medicine. It’s just being introduced to many physicians, hospitals and clinics. Pharmacogenetics is a science that holds enormous promise, and will doubtless reduce medical costs and increase the effectiveness of many drugs in the future.

Q: What is the impact of Adverse Drug Reactions?

View our Adverse Drug Events page for a detailed answer on the impact adverse drug reactions.

Q: How well established is the science?

The science of pharmacogenetics is both well established and rapidly changing. That specific genes influence how individual react to medications is not in doubt. The genes have, in most cases, been identified, and variations in those genes tracked. The effect those variations have on specific medications, however, is sometimes less well established. For some drugs the effects are well documented and indicate specific changes in dosages. For others, therapeutic changes are not as well documented.

View our Resources page for additional resources on pharmacogenetic testing.

View our list of drugs that have been fully researched.

Q: What drugs does pharmacogenetic testing apply to?

The effect genetic variations have on specific medications is well documented for some drugs, and not well documented for others. In general, drugs with a very narrow effective dosing range have been researched, while drugs with a wide effective range have not.

Genelex currently offers DNA Drug Sensitivity Testing that test CYP2D6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, NAT2, and CYP1A2 functionality. The downloadable drug list has many commonly prescribed drugs that are metabolized through these pathways in the Cytochrome P-450 system.

The FDA has updated the label of more than 30 drugs to include pharmacogenetic information.

Q: When is DNA sensitivity testing indicated?

If a patient takes four or more medications regularly or has had an adverse reaction that resulted in a doctor or emergency room visit, then they may benefit from DNA sensitivity testing powered by YouScript.

Also, a combination of the following conditions indicates an increased risk of adverse reactions to medications. Pharmacogenetic testing powered by the YouScript decision support tool may help reduce the risk.

  • Over 65 years of age
  • Experiencing unwanted side effects from medication(s)
  • Feels their medications aren’t working
  • Currently taking or considering any of the medications on this list
  • Has one or more of the following medical conditions:
    • acid reflux
    • mental health condition
    • arthritis
    • cancer
    • asthma/COPD
    • thyroid disorder
    • organ transplant
    • diabetes
    • osteoporosis
    • blood pressure (high)
    • cholesterol (high)
    • migraines
    • peptic ulcer
    • depression
    • prostate (enlarged)
    • depression
    • arthritis
    • pregnancy
    • post MI surgery

References
http://www.ncbi.nlm.nih.gov/pubmed/1753048
http://www.fda.gov
http://www.medsandaging.org/

Q: Where do I find additional research?

We would be happy to provide you with some of the latest pharmacogenetic research that applies to your area of practice. Please call 800-TEST-DNA (800-837-8362) to speak with a Medical Accounts Specialist. For a nice summary regardless of specialty, we highly recommend the following:

Pharmacogenetics: From Bench to Byte— An Update of Guidelines

Pharmacogenetic biomarkers as tools for improved drug therapy; emphasis on the cytochrome P450 system

Q: How much does pharmacogenetic testing cost?

Private Insurance covers pharmacogenetic testing in many diagnostic situations including adverse drug reactions or lack of response to medication, pain management, cancer management, and management of many co-morbid conditions.  Medicare coverage varies by plan; Medicare Advantage covers in many instances and traditional Medicare covers testing in some select cases.

The CPT codes (provided for your guidance only) if you would like to confirm eligibility in advance. Please call 800-TEST-DNA (800-837-8362) for cash pay pricing.

CYP2D6 CPT code 81226
CYP2C9 CPT code 81227
CYP2C19 CPT code 81225
CYP3A4 CPT code 81401
CYP3A5 CPT code 81401
CYP1A2 CPT code 81479-Unlisted Code
NAT2 CPT code 81479-Unlisted Code
DPD Enzyme CPT code 81400
UGT1A1 code 81350
5HTT code 81479-Unlisted Code

Q: How do I order?

View our How To Order page for a detailed answer.

Q: What are your laboratory qualifications?

View our Accreditations page to view our qualifications.

Q: How do I interpret pharmacogenetic test results?

In addition to easy to read genetic test reports and accompanying drug-gene interaction tables, Genelex includes access to YouScript with each test result. In addition to the genetic test results, all medications, herbals, and over-the-counters a patient is actively taking should be added to YouScript. This analysis gives healthcare providers the tools to better understand the potential risks of a patient’s medication regimen. If needed, healthcare providers can modify dosage or select alternate medications.

We are also available to answer any questions you may have or provide free web trainings, just call 800-TEST-DNA (800-837-8362) and ask for a Medical Accounts Specialist.

Q: Will Insurance cover Genelex pharmacogenetic (cytochrome) testing?

Private Insurance covers pharmacogenetic testing in many diagnostic situations including adverse drug reactions or lack of response to medication, pain management, cancer management, and management of many co-morbid conditions.  Medicare coverage varies by plan; Medicare Advantage covers in many instances and traditional Medicare covers testing in some select cases.

The CPT codes (provided for your guidance only) if you would like to confirm eligibility in advance. Please call 800-TEST-DNA (800-837-8362) for cash pay pricing.

CYP2D6 CPT code 81226
CYP2C9 CPT code 81227
CYP2C19 CPT code 81225
CYP3A4 CPT code 81401
CYP3A5 CPT code 81401

Tests not typically covered
(not part of the drug sensitivity panel and must be ordered separately)

CYP1A2 CPT code 81479-Unlisted Code
NAT2 CPT code 81479-Unlisted Code
DPD Enzyme CPT code 81400
UGT1A1 code 81350
5HTT code 81479-Unlisted Code
HLA-B*5701 CPT code 81381